Cell Adhesion: Sorting out Cell Mixing with Echinoid?
نویسنده
چکیده
Cadherins control intercellular adhesion in epithelial cells. This property relies on the ability to recruit actin filaments at adherens junctions via beta-catenin and alpha-catenin. A recent study shows that Echinoid, a member of the immunoglobulin domain containing protein family, is a modulator of intercellular adhesion in Drosophila that controls cell sorting.
منابع مشابه
Differential adhesion and actomyosin cable collaborate to drive Echinoid-mediated cell sorting.
Cell sorting involves the segregation of two cell populations into `immiscible' adjacent tissues with smooth borders. Echinoid (Ed), a nectin ortholog, is an adherens junction protein in Drosophila, and cells mutant for ed sort out from the surrounding wild-type cells. However, it remains unknown which factors trigger cell sorting. Here, we dissect the sequence of this process and find that cel...
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ورودعنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005